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您现在的位置: 医学全在线 > 理论教学 > 基础学科 > 医学免疫学 > 正文:旋毛形线虫(Trichinella spiralis)
    

旋毛形线虫

  Trichinella spiralis(Owen, 1835), which exhibits the most unusual life cycle, is the smallest nematode parasite of humans and also is the most widespread and clinically important organisms in the world. T. spiralis is responsible for the disease known as trichinosis, trichiniasis, or trichinelliasis. It is common in carnivorous mammals, including pigs, rodents and humans, primarily on the circumboreal continents and is less common in tropical region. Incidence of infection is always higher than suspected because of the vagueness of symptoms, which usually suggests other conditions; more than 50 different disease have been diagnosed incorrectly as trichinosis.

  Morphology

female

male

  Adults: The male measure 1.4-1.6mm long and are more slender at the anterior than at the posterior end. A copulatory spicule is absent. Females are about twice the size of males, also tapering toward the anterior end. The vulva is located near the middle of the esophagus, which is about a third of the length of the body. The single uterus is filled with developing eggs in its posterior portion, whereas the anterior portion contains fully developed, hatched juveniles.

  Cysts: The cysts encapsulates juveniles are spiral and located in the skeletal muscle.Although one worm per cyst is most common, up to seven have been observed in a single cyst within a single muscle cell.

肌肉切片

肌肉压片

  Life Cycle

  Ingest raw or poorly cooked: pork, bear, walrus, horse with viable larvae

  Excyst, invade gut mucosa

  4 larval stages

  Adult, deposit larvae

  Enter blood and lymph

  Enter body tissue, encyst in diaphragm, larynx, tongue, jaws, neck, ribs, biceps

  Become encapsulated

  Cyst wall is from host IR

  The larvae are viable for years; calcify

  It really does happen that way:

  Pathogenesis

  The pathogenesis of Trichinella infection can be considered in three successive stages: penetration of adult females into the mucosa, migration of juveniles, and penetration and encystment in muscle cells.

  First symptoms may appear between 12 hours and 2 days after ingestion of infected meat. Commonly, this phase is clinically inapparent because of low-grade infection or is misdiagnosed because of the vagueness of symptoms. When the gravid females penetrate the intestinal epithelium, they cause traumatic damage to the host tissues; they begin poisoning the host with their waste products, and they introduce enteric bacteria into the wounds they cause. These wounds result in intestinal inflammation and pain, with symptoms of food poisioning, such as nausea, vomiting, sweating, and diarrhea. Respiratory difficulties may occur, and red blotches erupt on the skin in some cases. This period usually terminates with facial edema and fever 5 to 7 days after the first symptoms.

  During migration, the newborn juveniles damage blood vessels, resulting in localized edema, particularly in the face and hands. Wandering juveniles may also cause pneumonia, pleurisy, encephalitis, meningitis, nephritis, deafness, peritonitis, brain or eye damage, and subconjunctival or sublingual hemorrhage. Death resulting form myocarditis (inflammation of the heart muscle)may occur at this stage. Although the juveniles do not stay in the heart, they migrate through its muscle, causing local areas of necrosis and infiltration of leukocytes.

  By the tenth day after the first symptoms appear, the juveniles begin penetration of muscle fibers. Attendant symptoms are again varied and vague: intense muscle pain, difficulty in breathing or swallowing, swelling of masseter muscles (occasionally leading to a misdiagnosis of mumps), weakening of pulse and blood pressure, heart damage, and various nervous disorders, including hallucination. Extreme eosinophilia is common but may not be present in even severe cases. Death is usually caused by heart failure, respiratory complications, toxemia, or kidney malfuction.

 

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