Positions are available to investigate synapse formation, synaptic plasticity and pathological mechanisms of brain disorders including schizophrenia and muscular dystrophy. For more information, please visit our lab’s website:
http://www.georgiahealth.edu/institutes/immag/meilab. Candidates should have PhDs in life sciences and are self-motivated for high-quality research. Strong background in biochemistry, electrophysiology, and/or behavioral analysis is ideal but not essential. The Georgia Regents University (previously Medical College of Georgia and Georgia Health Sciences University) is located in Augusta, Georgia, a historical city on the Savannah River famous for the Masters golf &nb
执业护士网sp;tournament and enriched life. Interested candidates should send CV and statement of research interests to Lin Mei at lmei@gru.edu.
Representative articles:
Y.Z. Huang et al., Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron 26:443-455, 2000
Z.G. Luo et al., Regulation of AChR Clustering by Dishevelled Interacting with MuSK and PAK1. Neuron 35:489-505, 2002.
R.-S. Woo et al., Neuregulin-1 Enhances Depolarization-Induced GABA Release. Neuron 54:599-610, 2007
X.-M. Li et al., Retrograde regulation of motoneuron differentiation by muscle β-catenin. Nature Neurosci. 11:262-268, 2008.
S. Luo et al., HSP90β Regulates Rapsyn Turnover and Subsequent AChR Cluster Formation and Maintenance. Neuron 60:97-110, 2008
B. Zhang et al., LRP4 serves as a co-receptor of agrin. Neuron 60:285-297, 2008
L. Wen et al., Neuregulin 1 regulates pyramidal&nbs医学全在线p; neuron activity via ErbB4 in parvalbumin-positive interneurons. Proc. Nat. Acad. Sci. USA 107:1211-1216, 2010
A. Ting et al., Neuregulin 1 promotes excitatory synapse development specifically in GABAergic interneurons. J. Neurosci. 31:15-25, 2011.
B. Zhang et al., Autoantibodies to LRP4 in double seronegative myasthenia gravis patients. Archive Neurol. 69:445-451, 2012
G.H. Tan et al., Neuregulin1 represses limbic epileptogenesis via activation of ErbB4 signaling in parvalbumin-positive interneurons. Nature Neurosci. 15:258-266, 2012
Y. Zong et al., Structural basis of neuron-specific regulation of postsynaptic differentiation. Genes & Development. 26:247-258, 2012 (Cover)
H.T. Wu et al., Distinct Roles of Muscle and motoneuron LRP4 in Neuromuscular Junction Formation. Neuron, 75:94-107, 2012.
H.T. Wu et al., beta-Catenin gain-of-function in muscles impairs neuromuscular junction formation. Development, 139:2392-2404.
C. Liang et al., Erbin is required for myelination in regenerated axons after injury. J. Neurosci., 32:15169-15180, 2012.
Y. Tao et al., Erbin interacts with TARP gamma-2 for surface expression of AMPA receptors in cortical interneurons. Nature Neurosci. 16:290-299, 2013.
Representative reviews:
L. Mei and W.C. Xiong. Neuregulin-1 signaling in neural development, synaptic plasticity and schizophrenia. Nature Rev. Neurosci. 9:437-452, 2008
H. Wu, Wen C. Xiong, L. Mei. To build a synapse: Signaling pathways in neuromuscular junction assembly. Development 137:1017-1033, 2010
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