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本研究通过肢体缺血再灌注损伤的动物实验表明，阿加曲班可以有效改善肢体缺血再灌注后的血液流变学异常。分析原因主要有以下2点：(1)降低血浆P选择素和ICAM1浓度，减少白细胞粘附，从而减轻全身炎性反应。(2)直接灭活凝血酶(因子Ⅱa)的活性，避免进一步促进凝血作用的级联反应,防止微血栓形成。综上所述阿加曲班表现出对缺血再灌注损伤的保护作用。
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