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您现在的位置: 医学全在线 > 医学论文 > 论文投稿 > 正文:基质金属蛋白酶_7及其组织抑制因子_1在胃癌中的表达与浸润、转移的关系研究
    

基质金属蛋白酶_7及其组织抑制因子_1在胃癌中的表达与浸润、转移的关系研究

来源:本站原创 更新:2013-9-5 论文投稿平台

基质金属蛋白酶_7及其组织抑制因子_1在胃癌中的表达与浸润、转移的关系研究

【摘要】 目的:探讨基质金属蛋白酶_7(MMP_7及其组织抑制因子_1(TIMP_1在胃癌中的表达与浸润、转移的关系。方法:应用免疫组化检测36例胃癌标本中肿瘤组织及癌旁组织中MMP_7和TIMP_1的表达,并进行回顾性随访。结果:胃癌组织中MMP_7阳性表达率(58.3%明显高于癌旁组织(5.6%,P<0.01,胃癌组织中TIMP_1阳性表达率(44.4%与癌旁组织(50.0%无统计学意义。胃癌中MMP_7和TIMP_1之间表达强度关系无明显相关性。TIMP_1表达随胃癌TNM分期增加而减少(P<0.05。结论:MMP_7表达与胃癌组织学行为有关,TIMP_1可能抑制胃癌的浸润、转移。

【关键词】 胃癌;基质金属蛋白酶_7;基质金属蛋白酶抑制因子_1

Expression of Matrix Metalloproteinase_7 and Tissue Inhibitor of Metalloproteinase_1

in Gastric Carcinoma: Exploration Mechanism of Invasion and MetastasisSUN Shu_ming,LU Xiao_feng,WU Lie,LIN Xiao_hong,LIN Hao_yu

(Department of General Surgery,The First Affiliated Hospital,Shantou University Medical College,Shantou 515041,China[Abstract]Objective:To investigate the expression of matrix metalloproteinase_7(MMP_7and tissue inhibitor of metalloproteinase_1(TIMP_1in gastric carcinoma and their relationship with tumor cell invasion and metastasis. Methods:The immunohistochemistry was used to detect the expression of MMP_7 and TIMP_1 in 36 patients with gastric carcinoma. Results: The positive expression rate of MMP_7(58.3%in gastric carcinoma was higher than that of paracarcinoma mucosa(5.6%(P<0.05,there was no difference of the expression of TIMP_1 between gastric cancer(44.4%and paracarcinoma mucosa(50.0%. The expression of TIMP_1 decreased with the increase of TNM staging(P<0.05. Conclusion: The expression of MMP_7 is related to the behavior of gastric carcinoma,and the expression of TIMP_1 probably inhibits tumor cell metastasis医.学全.在.线网站www.lindalemus.com.

[Key Words]gastric carcinoma,matrix metalloproteinase_7,tissue inhibitor of metalloproteinase_1


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