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医学论文范文:清热降浊方对2型糖尿病合并代谢综合征患者胰岛β细胞功能的影响
【摘要】 目的 探讨清热降浊方对2型糖尿病合并代谢综合征患者胰岛β细胞功能的影响。方法 采用随机对照的临床试验,观察清热降浊方(治疗组)与二甲双胍(对照组)对208例2型糖尿病合并代谢综合征患者糖化血红蛋白(HbA1c)、空腹血糖(FBG)、餐后2 h血糖(P2BG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、体重、体重指数(BMI)、腰围及胰岛素抵抗指数(HOMA2-IR)、胰岛素敏感指数(HOMA2-S)、胰岛β细胞功能指数(HOMA2-B)的影响。结果 2组患者治疗后HbA1c、FBG和P2BG水平均较治疗前明显下降(P<0.001),组间差异无统计学意义;TC、TG、LDL-C水平较治疗前均有所下降,但对HDL-C的作用不明显。治疗组体重与BMI下降明显,优于对照组(P<0.05)。2组HOMA2-IR、HOMA2-S、HOMA2-B的改善不明显。结论 清热降浊方对2型糖尿病合并代谢综合征患者各项指标的影响与二甲双胍相当,但对胰岛β细胞功能的改善不明显。
【关键词】 清热降浊方;二甲双胍;2型糖尿病;代谢综合征;胰岛β细胞功能
Effect of Qingre-Jiangzhuo Prescription on Islet β Cell Function of Type 2 Diabetes Mellitus Combined Metabolic Syndrome Patients ZHU Yan, LIAN Feng-mei, TONG Xiao-lin (Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China医学.全在线www.lindalemus.com)
Abstract：Objective To evaluate the effect of Qingre-Jiangzhuo prescription on islet β cell function of type 2 diabetes mellitus (T2DM) combined metabolic syndrome patients. Methods Two hundred and eight T2DM patients were divided into 2 groups in a randomized, controlled clinical trail. One group was treated by metformin tablet and the other by Qingre-Jiangzhuo prescription, both for 12 weeks. HbAlc, FBG, P2BG, TC, TG, LDL-C, BW, BMI, WC and HOMA2-IR, HOMA2-S, HOMA2-B level before and after treatment were recorded. Results After treatment, FBG, P2BG and HbAlc of the treated group were significantly lower than that before treatment (P<0.001), the difference between the two groups was not significant. TC, TG and LDL-C of both groups were significantly lower than that before treatment, but not in HDL-C. Weight and BMI were significantly decreased in the treated group compared with the control group (P<0.05). But the difference in HOMA2-IR, HOMA2-S, HOMA2-B were not significant. Conclusion Qingre-Jiangzhuo prescription was same as metformin tablet in T2DM combined metabolic syndrome patients, while not in β cell function.
Key words：Qingre-Jiangzhuo prescription;metformin;T2DM;MS;islet β cell function
前期研究显示,清热降浊方与二甲双胍有相似的降糖、调脂、减肥等作用,且安全性良好[1-2]。为进一步探讨清热降浊方对2型糖尿病合并代谢综合征患者胰岛β细胞功能的影响,笔者拟通过随机对照的临床试验,对患者的胰岛素抵抗指数(HOMA2-IR)、胰岛素敏感指数(HOMA2-S)、胰岛β细胞功能指数(HOMA2-B)进行观察。
1 资料与方法
