【参考文献】
[1] Dauer W,Przedborski S.Parkinson's disease: mechanisms and models[J].Neuron,2003, 39(6):889-909.
[2] Maragakis NJ, Rothstein JD. Mechanisms of Disease: astrocytes in neurodegenerative Disease[J].Nat Clin Pract Neurol,2006, 2(12):679-689.
[3] Gee JR,Keller JN.Astrocytes: regulation of brain homeostasis via apolipoprotein E[J].Int J Biochem Cell Biol,2005,37(6):1145-1150.
[4] Knott C, Stern G,Wilkin GP.Inflammatory regulators in Parkinson's disease:iNOS, lipocortin-1, and cyclooxygenases-1 and-2[J].Mol Cell Neurosci,2000,16(6):724-739.
[5] Ekdahl CT,Claasen JH,Bonde S,et al.Inflammation is detrimental for neurongenesis in adult brain[J].Proc Natl Acad Sci USA,2003,100(23):13632-13637.
[6] Kohutnicka M,Lewandowska E,Kurkowska-Jastrzebska I,et al.Microglial and astrocytic involvement in a murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)[J].Immunopharmacology,1998,39(3):167-180.
[7] Czlonkowska A,Kurkowska-Jastrzebska I, Czlonkowski A,et al.Immune processes in the pathogenesis of Parkinson's disease-a potential role for microglia and nitric oxide[J].Med Sci Monit,2002,8(8):RA165-177.
[8] Saha RN, Pahan K.Regulation of inducible nitric oxide synthase gene in glial cells[J]. Antioxid Redox Signal,2006,8(5-6):929-947医学 全在.线提供www.lindalemus.com.
[9] Liu B.Modulation of microglial pro-inflammatory and neurotoxic activity for the treatment of Parkinson's disease[J].AAPS J,2006,8(3):E606-621.
[10] Purisai MG,McCormack AL,Cumine S,et al.Microglial activation as a priming event leading to paraquat-induced dopaminergic cell degeneration[J]. Neurobiol Dis,2007,25(2):392-400.
[11] Saavedra A,Baltazar G,Santos P,et al.Selective injury to dopaminergic neurons up-regulates GDNF in substantia nigra postnatal cell cultures: role of neuron-glia crosstalk[J].Neurobiol Dis,2006,23(3):533-542.
[12] Jakel RJ, Kern JT, Johnson DA, et al.Induction of the protective antioxidant response element pathway by 6-hydroxydopamine in vivo and in vitro[J].Toxicol Sci,2005,87(1):176-186.
[13] Knyihar-Csillik E,Chadaide Z,Mihaly A,et al.Effect of 6-hydroxydopamine treatment on kynurenine aminotransferase-I(KAT-I) immunoreactivity of neurons and glial cells in the rat substantia nigra[J].Acta Neuropathol(Berl),2006,112(2):127-137.