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医学论文范文:银杏叶提取物治疗抗抑郁剂所致不良反应对照研究
【摘要】 目的 探讨银杏叶提取物缓解抗抑郁剂治疗初期所致不良反应的临床效果。 方法 将100例抑郁症患者随机分为两组各50例，研究组给予抗抑郁剂联合银杏叶提取物注射液治疗，对照组单用抗抑郁剂治疗，观察6 w。于治疗前和治疗第1 w、2 w、3 w、4 w、5 w、6 w末采用汉密顿抑郁量表、汉密顿焦虑量表及抑郁自评量表、焦虑自评量表评定临床疗效，并记录两组不良反应。 结果 两组治疗后各周末汉密顿抑郁量表、汉密顿焦虑量表及抑郁自评量表、焦虑自评量表评分均较治疗前显著下降（P＜0.01)，并随着治疗时间的延续均呈持续性下降；治疗各周末研究组均较对照组下降显著（P＜0.05或0.01)。研究组治疗第1 w、2 w、3 w末不良反应发生率显著低于对照组（P＜0.05或0.01)，4 w末起两组无显著性差异（P＞0.05)。 结论 银杏叶提取物注射液能有效缓解抗抑郁剂治疗初期所致的不良反应，显著提高治疗依从性。
【关键词】 抑郁症；银杏叶提取物；抗抑郁剂；不良反应；汉密顿抑郁量表；汉密顿焦虑量表；抑郁自评量表；焦虑自评量表
A control study of Ginaton relieving adverse reactions caused by antidepressant at initial stage
Wang Xiuhong,Hu Wei
(Psychological Department, Nandi Hospital of Bengang,Benxi 117000,Liaoning,China)
【Abstract】 Objective To explore the clinical efficacy of Ginaton relieving adverse reactions caused by antidepressant at initial stage.Methods One hundred hospitalized depression patients were randomly assigned to research group(n=50) treated with antidepressant plus Ginaton injection and control group(n=50) with single antidepressant for 6 weeks. Clinical efficacies were assessed with the Hamilton Depression Scale(HAMD), the Hamilton Anxiety Scale(HAMA), the Selfrating Depression Sacle(SDS) and the Selfrating Anxiety Scale(SAS) before treatment and at the ends of the 1st,2nd,3rd,4th,5th and 6th week treatment, and adverse reactions recorded. Results After treatment, scores of the HAMD,HAMA,SDS and SAS of both groups all lowered more significantly compared with pretreatment(P<0.01) and did continously along with time of therapy lasting; those lowered more significantly at each weekend in the research than in the control group(P<0.05 or 0.01). incidences of adverse reactions were significantly lower in the research than in the control group at the ends of the first three week(P<0.05 or 0.01),there were no significant differences between the 2 groups since the end of the 4th week(P>0.05).Conclusion Ginaton injection can effectively relieves adverse reactions caused by antidepressant at initial stage, improve drug’s compliance and augment drug’s efficacy医.学全.在.线网站www.lindalemus.com.
【Keywords】 Depression; Ginaton; antidepressant;adverse reactions;HAMD;HAMA;SDS;SAS
5羟色胺再摄取抑制剂（SSRIs)抗抑郁剂类治疗抑郁症临床效果显著，但服药后常在治疗初期出现诸多的不良反应，影响了患者服药物的依从性，进而影响疗效。为了减轻或缓解SSRIs类药物治疗初期出现的不良反应，改善患者躯体和情绪症状，作者对应用SSRIS类药物治疗的抑郁症患者联合静脉滴注银杏叶提取物进行了相关对照研究，现将结果报告如下。
1 对象与方法
1.1 对象 选取2007年5月～2007年12月在我院心理科住院的抑郁症患者为研究对象。入组标准：（1)符合《中国精神障碍分类与诊断标准》第3版（CCMD3)［1］抑郁发作诊断标准。（2)汉密顿抑郁量表（HAMD)≥20分，汉密顿焦虑量表（HAMA)≥14分，抑郁自评量表（SDS)＞53分，焦虑自评量表（SAS)＞50分。（3)文化程度在初中以上，年龄18 a～60 a。（4)首次服SSRIs类药物。（5)排除严重躯体疾病、实验室检查严重异常者、严重自杀倾向者、药物或酒精过敏、妊娠或哺乳妇女及双相情感障碍快速循环相等精神障碍者。共入组100例，随机分为两组各50例。研究组男21例，女29例，平均年龄（31±7) a，平均病程（3.2±0.4) a。对照组男24例，女26例，平均年龄（30±8) a，平均病程（3.1±0.6) a。
1.2 方法
