 |
 |
医学免费论文:中性粒细胞/淋巴细胞比率对急性心肌梗死患者临床并发症的预测价值
【摘要】 目的： 探讨中性粒细胞/淋巴细胞比率(NLR)与急性心肌梗死(AMI)患者临床并发症之间的关系。 方法： 入选急性ST段抬高心肌梗死(STEMI)患者218例,入院后即刻抽取静脉血查血常规,按中性粒细胞/淋巴细胞比率的大小由小到大将其分为A、B两组,对两组急性心肌梗死并发症发生率进行比较。 结果： 两组肌钙蛋白峰值分别为(32.5±21.7)ng/ml和(56.8±39.4)ng/ml,B组高于A组,差异具有统计学意义(P<0.01)。心律失常(17.43%和39.45%,P<0.01)、心力衰竭(22.94%和51.38%,P<0.01)及猝死发生率(2.75%和11.01%,P<0.05)B组均显著高于A组,差异具有统计学意义。多元逐步回归分析显示NLR与AMI并发症发生率具有显著的相关性(P<0.05)。结论： 中性粒细胞/淋巴细胞比率是急性心肌梗死患者临床并发症的可靠预测指标。
【关键词】 中性粒细胞/淋巴细胞比率; 急性心肌梗死; 临床并发症; 预后
Usefulness of the neutrophil to lymphocyte ratio in predicting complications
in patients with acute myocardial infarction
LU Yi1, FU Qiang2, LIU Yi2, SHENG Yang1, WEI Peng1
(1. School of Medicine, Jiangsu University, Zhenjiang Jiangsu 212013; 2.Department of Cardiology, the Central Hospital of Xuzhou, Xuzhou Jiangsu 221009, China)
[Abstract] Objective: To investigate the relationship between the neutrophil to lymphocyte ratio and the morbidity of AMI complications. Methods： A total of 218 patients with ST segment elevated myocardial infarction whose blood routines were obtained at the admission were studied. All cases were divided into two groups according to the neuropil to lymphocyte ratio of small to large size. Then we analyzed the morbidity of AMI complications between the two groups. Results： The peak value of cardiac troponin I was higher in group B[(32.5±21.7) ng/ml and (56.8±39.4) ng/ml respectively, P<0.01]. The incidences of arrhythmia (17.43% and 39.45%,P<0.01), heart failure (22.94% and 51.38%,P<0.01) and death (2.75% and 11.01%,P<0.05) were also higher in group B. The multivariate stepwise regression analysis showed that the neutrophil to lymphocyte ratio and the morbidity of AMI complications had significant correlation. Conclusion： The neutrophil to lymphocyte ratio was a reliable indicator that can predict morbidity of AMI complications医.学.全.在.线www.lindalemus.com.
[Key words] neutrophil to lymphocyte ratio; acute myocardial infarction; complication; prognosis
大量研究表明,动脉粥样硬化是一种复杂的,与多种因素有关的疾病。炎症反应在此过程中具有重要的作用。许多不同的炎症指标,如C反应蛋白、白细胞等,被认为是上述疾病过程重要的生物学标志物。近年来,对白细胞分类计数的研究越来越多。研究显示[1],中性粒细胞/淋巴细胞比率(NLR)对急性冠脉综合征(acute coronary syndrome, ACS) 诊断及预后具有重要价值。国内关于中性粒细胞/淋巴细胞比率与急性心肌梗死(acute myocardial infarction, AMI)预后的研究尚少。本研究旨在探讨中性粒细胞/淋巴细胞比率与急性心肌梗死患者临床并发症之间的关系。
