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医学免费论文:血脂康对高脂血症患者血脂、血管内皮功能及颈动脉内膜中层厚度的影响
【摘要】 目的：观察血脂康对高脂血症患者血脂水平、血管内皮功能及颈动脉内膜中层厚度(IMT)的影响。方法：110例高脂血症患者随机分为观察组和对照组，各55例，观察组予血脂康胶囊1次0.6g，1天2次，口服，12周;对照组予普伐他汀片1次20mg，1天1次，口服，12周。测定两组治疗前后血甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)、高密度脂蛋白胆固醇(HDLC)、血内皮素(ET)、一氧化氮(NO)水平及颈动脉内膜中层厚度 (IMT)。结果：与治疗前比较，治疗后两组TG、TC、LDLC降低，HDLC升高，差异均有统计学意义(P<0.05);两组治疗后ET降低，NO升高，与治疗前比较差异有统计学意义(P<0.05);两组治疗后IMT降低与治疗前比较也有统计学意义(P<0.05)。观察组与对照组比较，治疗后TG、TC、LDLC降低及HDLC升高均无统计学意义(P>0.05)，但ET降低和NO升高差异有统计学意义(P<0.05);两组IMT比较无统计学意义(P>0.05)。结论：血脂康1天1.2g调脂、逆转颈动脉内膜中层厚度的效果与普伐他汀1天20mg相同，但改善血管内皮功能作用强于普伐他汀。
【关键词】 高脂血症 血脂康 内皮素 一氧化氮 颈动脉内膜中层厚度
Effect of Xuezhikang on Blood Lipid Levels,Endothelial Function and Carotid Intimamedia Thickness in Patients with Hyperlipidemia WANG Min,YAO Qiang,WANG Shisheng.Department of Cardiology,Zhejiang Traditional Chinese Medicine and Western Medicine Hospital,Hangzhou (310003) China
Abstract Objective:To study the effects of Xuezhikang(XZK) on blood lipid levels,endothelial function and carotid intimamedia thickness in patients with hyperlipidemia.Methods:A total of 110 patients with hyperlipidemia were randomly allocated to observation group (XZK 1.2g/day 12 week,n=55) and control group (pravachol 20 mg/day 12 week,n=55).Serum levels of triglyceride(TG),total cholesterol(TC),lowdensity lipoproteincholesterol(LDLC),highdensity lipoproteincholesterol(HDLC),endothelin (ET),and nitric oxidate (NO) were determined and carotid intimamedia thickness(IMT) was measured before and after treatment in both groups.Results:After treatment,TG,TC,and LDLC were significantly decreased and HDLC increased in both groups(P<0.05);ET markedly decreased and NO increased in both groups(P<0.05);Carotid IMT significantly decreased in both groups(P<0.05),as compared with those before treatment.Except for the changes of ET and NO(P<0.05),the difference of other parameters did not reach a significant value between the 2 groups (P>0.05).Conclusion:XZK (1.2g/day) can correct the abnormal blood lipids,improve the endothelial function and reverse carotid IMT in patients with hyperlipidemia,with an equivalent effect to pravachol(20 mg/day) in adjusting blood lipids and reversing carotid IMT,but a stronger effect in improving endothelial function医.学全.在.线网站www.lindalemus.com.
Key words hyperlipidemia Xuezhikang endothelin nitric oxide carotid intimamedia thickness
高脂血症可致血管内皮功能异常，甚至高脂血症患者即使在没有明确的动脉粥样硬化形成时即有内皮功能障碍,调脂治疗可使之明显改善[1，2]。血脂康是采用生物技术从特制红曲中提炼精制而成的血脂调节剂,已经证实可以有效并安全调节血脂异常 [3]。本研究旨在观察血脂康对高脂血症患者血脂、血一氧化氮(NO)、内皮素(ET)水平及颈动脉内膜中层厚度(IMT)的影响，探讨其血管内皮保护功能及逆转颈动脉IMT作用。
1 临床资料
