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Human vaccines & immunotherapeutics


Human vaccines & immunotherapeutics
影响因子: 3.136
I S S N: 1554-8600
出 版 社: Landes Bioscience
出 版 地: Georgetown, Tex
出版国家: United States
刊  期: 月刊
创刊时间: 2005
语  种: 英文
审稿周期: 平均2月
中科院分区:
投稿命中率: 约50%
国外数据库收录: IM
中国收录文章数: 24
5年影响因子: 3.309
研究领域: 疫苗
官方链接: http://www.landesbioscience.com/journals/vaccines/
投稿须知: http://www.landesbioscience.com/journals/vaccines/

期刊介绍:

Since the introduction of DNA vaccines two decades ago, this attractive strategy has been hampered by its low immunogenicity in humans. Studies conducted to improve the immunogenicity of DNA vaccines have shown that understanding the mechanism of action of DNA vaccines might be the key to successfully improving their immunogenicity. Our current understanding is that DNA vaccines induce innate and adaptive immune responses in two ways: (1) encoded protein (or polypeptide) antigen(s) by the DNA plasmid can be expressed in stromal cells (i.e., muscle cells) as well as DCs, where these antigens are processed and presented to na?ve CD4 or CD8 T cells either by direct or cross presentation, respectively; and (2) the transfected DNA plasmid itself may bind to an un-identified cytosolic DNA sensor and activate the TBK1-STING pathway and the production of type I interferons (IFNs) which function as an adjuvant. Recent studies investigating double-stranded cytosolic DNA sensor(s) have highlighted new mechanisms in which cytosolic DNA may release secondary metabolites, which are in turn recognized by a novel DNA sensing machinery. Here, we discuss these new metabolites and the possibilities of translating this knowledge into improved immunogenicity for DNA vaccines.
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