8-Azabicyclo[3,2,1]octane-2,6-diol,6-acetate(exo,exo)-(-)-

Erycibe alkaloid Ⅱ

包公藤甲素

Baogongteng A

185.11

白色粘状物,[α]20/D-5.56°(C=0.90,CHCl3)。苯甲酸盐:白色细针状结晶(苯或丙酮),熔点160～161°,易溶于水,能溶于氯仿及热苯,难溶于乙醚。IR λKBrmax cm\-1:3400(m),2950(m),1740(s),1640(w),1380(m),1260(s,特宽),1190(m),1035(m),1000(w),950(w),885(w);MSm/e(%):185(M+,13.5),166(1.9),142(24.4),128(10.5),126(44.8),125,108,99(100),98,96,85,83,82(47.5),81,80(93.3),70,69,68,67,57,56,45,43,41,31,30,29,28,27;高分辨MSm/e(%):185.1055(14.1),142.0876(23.6),128.0715(10.0),126.0918(47.3),125.0838(24.6),99.0687(96.3),98.0610(31.6),96.0817(10.3),82.0656(44.3),81.0573(43.6),80.0500(100.0),78.0473(18.2);NMR(CDCl3)δ:1.0～2.4(6H,m),1.98(3H,s),2.6～2.8(2H,s),3.2～3.4(1H,m),3.4～3.6(2H,m),5.0～5.2(1H,dd,J=8,3～4);13CNMR(CDCl3)δ:173.277(s),171.305(s),135.181(s),131.769(p),129.945(d),128.250(d),74.717(d),66.573(d),60.221(d),34.001(t),24.413(t),22.901(t),20.389(q)。

本品苯甲酸盐配成0.025%的眼药水,其缩瞳效果比毛果芸香碱的作用强100倍。0.025%溶液0.5ml家兔静脉注射,具有明显的降低血压的作用。临床用于治疗青光眼有显著疗效,经159例239只青光眼试用,在青光眼缩小瞳孔、降低眼压和改善房水流畅系数方面均有显著作用,本品无不良反应,局部副作用轻,是治疗青光眼比较理想的药物。

旋花科丁公藤属植物丁公藤(包公藤) Erycibe obtusifolia Benth.茎。

1.《植物药有效成分手册》人民卫生出版社1986

C9H15NO3