Maytansine,N2'-deacetyl-N2'-(2-methyl-1-oxopropyl)-

Maytanbutine

720.26

熔点170～1°,[α]30/D-122°(C=0.092,氯仿)。UV λEtOHmax nm(ε):234(33100),243(sh,30400),254(30500),282(6430),290(6380)。IR λKBrmaxμ:5.72,5.79,6.04,6.06,6.34,8.44,9.28。MSm/e:658.3030[M-61(H2O+HNCO)]。NMR(CDCl3)δ:0.88(3H,s,C-4CH3),1.12(3H,d,J=7,C-4'CH3),1.19(3H,d,J=7,C-4'CH3),1.35(3H,d,J=6,C6CH3),1.36(3H,d,J=6,C-2'CH3),1.70(3H,br、s,C-14CH3),2.20(1H,dd,J2,2=14,J2,3=3,C-2H),2.65(1H,dd,J2,2=14,J2,3=12,C-2H),2.80(1H,m,C-4'H),2.87(0.75H,s)和2.92(2.25H,s,C-2'NCH3),3.04(1H,d,J5,6=9,C-5H),3.12(1H,d,J15,15=13,C-15H),3.20(3H,s,C-1NCH3),3.37(3H,s,C-10OCH3),3.51(1H,d,J10,11=9,C-10H),3.52(1H,S,C-9OH),3.68(1H,d,J15,15=13,C-15H),4.00(3H,s,C-20 OCH3),4.29(1H,m,C-7H),4.78(1H,dd,J2,3=12,3),5.39(1H,q,J=7,C-2'H),5.64(1H,dd,J10,11=9,J11,12=15,C-11H),6.25(1H,br.s,C-9NH),6.43(1H,dd,J11,12=15,J12,13=11,C-12H),6.79(1H,br、d,J12,13=11,C-13H),6.66,6.82(2H,d,J17,21=1.5,C-17H,C-21H),0.80～2.00(3H,C-6H,C-8H2)。

抗癌。对小鼠淋巴白血病P388和鼻咽癌KB细胞都有很强的活性,在最佳剂量0.8mg/kg时,对P388的生命延长率为90%,对KB细胞培养的细胞毒活性ED50为0.0000036μg/ml。

卫矛科植物山檨美登木 Maytenus buchananii(Loes.)R.Wilczek 卵叶美登木 M.ovatus Loes. 齿叶美登木 m.serrata R.Wilczek 果实 南非产卫矛科植物普特里基木 Putterlickia verrucosa Szyszyl.茎 鼠李科植物得克萨斯蛇藤 Colubrina texensis A.Gray。

1.《植物药有效成分手册》人民卫生出版社1986

C36H50ClN3O10