Maytansine,O3-acetyl-O3-de[2-(acetylmethylamino)-1-oxopropoxy]-

Maytanacine

Maytansinol acetate

606.5

熔点234～7°(二氯甲烷-己烷),[α]23/D-119°(C=0.100,氯仿)。UV λEtOHmax nm(ε):233(30300),242(肩,28000),252(27900),281(5360),289(5360);IR λKBrmaxμ:5.70,5.80,6.00,6.34;MSm/e:545.2180,485.1969;NMR(CDCl3)δ:0.84(3H,s,C-4CH3),1.28(3H,d,J=6,C-6CH3),1.69(3H,s,C-14CH3),2.18(3H,s,C-3OCOCH3),2.05～2.30(1H,C-2H),2.46(1H,dd,J2,3=12,J2,2=14,C-2H),2.89(1H,d,J5,6=9,C-5H),3.18(3H,s,C-1NCH3),3.36(3H,s,C-10 OCH3),3.52(1H,d,J10,11=9,C-10H),3.10～3.60(3H,C-9 OH,C-15 H2),3.99(3H,s,C-20OCH3),4.16(1H,m,C-7H),4.92(1H,dd,J2,3=3.12,C-3H),5.48(1H,dd,J10,11=9,J11,12=15,C-11H),6.10～6.59(3H,C-9NH,C-12H),6.84,6.76(2H,s,C-17H,C-20H),0.80～2.50(3H,C-6H,C-8H2)。

有抗癌作用。对小鼠淋巴白血病P388和鼻咽癌KB细胞都有很强的活性,在最佳剂量100μg/kg时,P388的生命延长率为130%,对KB细胞培养的细胞毒作用ED50为10\-5μg/ml。

卫矛科植物普特里基木 Putterlickia verrucosa Szyszyl.茎。

1.《植物药有效成分手册》人民卫生出版社1986

C30H39ClN2O9