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 医学全在线 > 考研院校 > 华东地区2 > 浙江大学医学院 > 院系导师 > 正文
浙江大学医学院研究生硕士生导师简介:杨军
来源:浙江大学 更新:2007/5/30 字体:


业绩一览:
一、发表文章:
1.Yang, J. and Duerksen-Hughes, P. (1998) A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage. Carcinogenesis, 19, 1117-1125
2.Duerksen-Hughes, P., Yang, J., and Oczan, O. (1999) p53 induction as a genotoxic test for twenty-five chemicals undergoing in vivo carcinogenicity testing. Env. Health
Persp., 107, 805-812
3.Duerksen-Hughes, P., Yang, J., and Schwartz, S. (1999) HPV 16 E6 blocks TNF-mediated apoptosis in mouse fibroblast LM cells. Virology, 264, 55-65
4.Yang, J. and Duerksen-Hughes, P. (2001) Activation of a p53 independent, sphingolipid-mediated cytolytic pathway in p53-negative mouse fibroblast cells treated with N-methyl-N-nitro-N-nitrosoguanidine. J. Biol. Chem., 276, 27129-27135
5.Yang, J.*, Hooper, W. C., Phillips, D., and Talkington, D. (2002) Regulation of proinflammatory cytokines in human lung epithelial cells during Mycoplasma pneumoniae infection. Infect. Immun., 70, 3649-3655.
6.Yang, J., Hooper, W. C., Phillips, D., Tondella, M., and Talkington, D. (2002) Centrifugation of human lung epithelial carcinoma A549 cells up-regulates interleukin-1beta gene expression. Clin. Diagn. Lab. Immunol. 9, 1142-1143.
7.Yang, J., Hooper, W. C., Phillips, D., Tondella, M., and Talkington, D. (2003) Induction of proinflammatory cytokines in human lung epithelial cells during Chlamydia pneumoniae infection. Infect. Immun. 71, 614-620.
8.Yang, J., Hooper, W. C., Phillips, D., and Talkington, D. (2003) Interleukin-1beta responses to Mycoplasma pneumoniae infection are cell-type specific. Microbial Pathog., 34, 17-25.
9.Yang, J., Yu, Y., and Duerksen-Hughes, P. (2003) Protein kinases and their involvement in the cellular responses to genotoxic stress. Mutat. Res.-Rev. Mutat. Res., 543, 31-58.
10.Zhu, F., Jin, C., Song, T., Yang, J., Guo, L., Yu, Y. (2003) Response of human REV3 gene to gastric cancer inducing carcinogen N-methyl-N’-nitro-N-nitrosoguanidine and its role in mutagenesis. World J. Gastroentol. 9, 888-893.
11.Jin, J., Gao, Z., Guo, L., Yang, J., and Yu, Y. (2003) Altered expression of zinc finger proteins, ADAMs, and integrin-related proteins following treatment of cultured human cells with a low concentration of N-methyl-N'-nitro-N-nitrosoguanidine. Environ. Mol. Mutagen. 41, 344-352.
12.Wang, Z., Wang, G., Yang, J., Guo, L., and Yu, Y. (2003) Activation of Protein Kinase A and Clustering of Cell Surface Receptors by N-methyl-N'-nitro-N-nitrosoguanidine are Independent of Genomic DNA damage. Mutat. Res. 528, 29-36.
13.Yang, J., Yu, Y., Hamrick, H. E., and Duerksen-Hughes, P. (2003) ATM, ATR, and DNA-PK: Initiators of cellular genotoxic stress response. Carcinogenesis, 24, 1571-1580.
14.Yang, J., Xu, Z., Huang, Y., Hamrick, H., Duerksen-Hughes, P., and Yu, Y. (2004) ATM and ATR: sensing DNA damage. World J. Gastroenterol. 10, 155-160.
15.Jin, J., Yang, J., Gao, Z., and Yu, Y. (2004) Proteomic Analysis of Cellular Responses to Low Concentration N-methyl-N’-nitro-N-nitrosoguanidine in human amnion FL cells. Environ. Mol. Mutagen. 43, 93-99.
16.Gao, Z., Jin, J., Yang, J., and Yu, Y. (2004) Zinc finger proteins and other transcription regulators as response proteins in benzo(a)pyrene exposed cells. Mutat. Res. 550, 11-24.
17.Yu, Y., Yang, J., Zhu, F., and Xu, F. (2004) Response of REV3 promoter to N-methyl-N-nitro-N-nitrosoguanidine. Mutat. Res., 550, 49-58.
18.Yang, J., Yu, Y., Sun, S., Duerksen-Hughes, P. (2004) Ceramide and other sphingolipids in cellular response. Cell Biochem. Biophys., 40, 323-350.
19.Yang, J., Phillips, D., Hooper, W. C., and Talkington, D. F. (2004) Cytokines in Mycoplasma pneumoniae infections. Cytokine Grow. Factor. Rev., 15, 157-168.
20.Shi, B., Cai, Z., Yang, J., and Yu, Y. (2004) N-methyl-N-nitro-N- nitrosoguanidine sensitivity, Mutator phenotype and Sequence specificity of spontaneous mutagenesis in FEN-1 deficient cells. Mutat. Res., 556, 1-9.
21.Gao, Z., Yang, J., Huang, Y., and Yu, Y. (2005) N-methyl-N-nitro-N-nitrosoguanidine interferes with the epidermal growth factor receptor-mediated signaling pathway. Mutat. Res., 570, 175-184.
22.Huang, Y., Yang, J.*, Shen, J., Chen, F., and Yu, Y. (2005) Sphingolipids are involved in N-methyl-N-nitro-N-nitrosoguanidine-induced epidermal growth factor clustering. Biochem. Biophys. Res. Commun., 330, 430-438.
23.Huang, Y., Shen, J., Wang, T., Chen, F., Yu, Y., and Yang, J.* (2005) A lipidomic study of the effects of N-methyl-N’-nitro-N-nitrosoguanidine on sphingomyelin metabolism. Acta Biochim Biophys Sinica, 37, 515-524. 
24.Zhou, C., Li, Z., Diao, H., Yu, Y., Zhu, W., Dai, Y., Chen, F.F., and Yang, J.* (2006) DNA damage evaluated by H2AX foci formation by a selective group of chemical/physical stressors. Mutat. Res., 604, 8-18.
25.Yu, Y., Zhu, W., Diao, H., Zhou, C., Chen, F.F., and Yang, J.* (2006) A comparative study of using comet assay and H2AX foci formation in the detection of N-methyl-N’-nitro-N-nitrosoguanidine. Toxicology in Vitro, 20, 959-965.
26.Luo, Q., Yang, J., Zeng, Q., Zhu, X., Qian, Y., and Huang, H. (2006) 50 Hz Electromagnetic Fields Induce gammaH2AX Foci Formation in Mouse Preimplantation Embryos in vitro. Biol. Reproduction, Published on July 19, 2006 as DOI:10.1095/biolreprod.106.052241
27.Li, Z., Yang, J.#, and Huang, H. (2006) Oxidative stress induces H2AX phosphorylation in human spermatozoa. FEBS Lett., In press.
28.Li, Z., Yang, J., and Huang, H. (2006) Adriamycin induces H2AX phosphorylation in human spermatozoa. Biol. Reproduction, In revision.
29.余应年,杨军. 化学诱变剂诱发基因非定标性突变的分子机理研究. 浙江大学学报医学版, 2003, 32:369-374.
30.金静华,高志华,杨军,余应年. 低浓度MNNG诱发FL细胞应答反应的蛋白组学研究. 浙江大学学报医学版, 2003, 32:375-379.
31.高志华,金静华,杨军,余应年. 苯并[a]芘诱导的FL细胞指蛋白等表达的改变. 浙江大学学报医学版, 2003, 32:380-384.
32.王政,王谷亮,杨军,余应年. 低浓度MNNG诱发非DNA损伤依赖的细胞信号通路. 浙江大学学报医学版, 2003, 32:385-389.
33.王谷亮,王政,杨军,余应年. 低浓度MNNG激活转录因子. 浙江大学学报医学版, 2003, 32:390-392.
34.朱峰,杨军,徐方,余应年. 人REV3基因启动子区的克隆和生物信息学分析及其对MNNG的反应. 浙江大学学报医学版, 2003, 32:393-397.
35.罗月球,杨军,余应年. POLH基因反义阻断细胞系的建立及POLH在MNNG引起的非定标性突变中的作用. 浙江大学学报医学版, 2003, 32:398-402.
36.黄韵,石为,吕丽华,余应年, 杨军*. 细胞DNA损伤应激反应中丝裂原活化蛋白激酶的信号通路. 国外医学(生理、病理科学与临床分册), 2004, 24:438-441.
37.黄韵,余应年,杨军*. 鞘脂类研究的进展. 浙江大学学报医学版, 2005, 34, 375-378.
38.余艳柯,陆源,余应年,杨军*. -H2AX: DNA双链损伤的标志. 中国药理学与毒理学杂志, 2005, 19, 237-240.
39.沈静,杨军,余应年. 质谱在蛋白组学中的应用. 中国病理生理杂志, 2005, 21, 2057-2061.
40.刁汇铃,周春仙,余艳柯,杨军*. 2-乙酰氨基芴诱导H2AX焦点的形成. 中国药理学与毒理学杂志,2006, 20, 131-137.
41.钱俊斌,钱聪,葛朝荣,杨军*. 杭州市自然水体中细菌耐药性分析. 浙江预防医学,2006, 18, 36-37.
42.周新妹,姚慧,夏满莉,曹春梅,蒋惠娣,夏强,杨军. 芦丁对离体大鼠主动脉环的舒张作用及相关机制. 中国药学杂志,2006, 41, 431-434.
43.王为民,夏强,王琳琳,陆源,历旭云,杨军*. 大黄素对大鼠主动脉非内皮依赖性的舒张作用及其机制研究. 中国药学杂志, 2006, 41, 505-508.
44.王为民,虞燕琴,钱令波,舒强,刘广义,林茹,杨军*. 大黄素对大鼠体外血管内皮一氧化氮cGMP信号途径的影响. 中国中西医结合杂志, 2006, 26, 636-639.
45.刁汇铃,朱心强,杨军*. 复制蛋白A功能的研究进展. 中国药理学与毒理学杂志,2006,印刷中.
46.石为,余艳柯,朱心强,杨军*. MNNG诱导CHL细胞中gammaH2AX焦点的形成. 癌变,畸变,突变,2006,印刷中.
47.余艳柯,董正伟,石为,刘广义,杨军*. MNNG在FL细胞中诱导一种特殊的gammaH2AX全核染色. 浙江大学学报医学版,2006,印刷中.
* 通讯作者   # 共同第一作者
二、大会报告:
1.Yang, J. and Duerksen-Hughes, P. (1996) p53 Induction as an indicator of genotoxic damage. FASEB J. 10(6):AI524, Experimental Biology Annual Meeting 1996, New Orleans, Louisiana
2.Duerksen-Hughes, P., Yang, J., and Schwartz, S. (1999) HPV 16 E6 blocks TNF-mediated apoptosis in mouse fibroblast LM cells. 17th International Papillomavirus Conference, Charleston, South Carolina
3.Duerksen-Hughes, P., Kale, M. D., Ozcan, O., Yang, J., and Zaki, M. (1999) Evaluation of the genotoxicity of chemicals currently undergoing in vivo carcinogenicity testing using the p53-induction assay. Toxicological Sciences, 1742, p369, SOT 1999 Annual Meeting, Seattle, Washington
4.Yang, J., Hooper, W. C., Phillips, D., and Talkington, D. (2001) Regulation of proinflammtory cytokines in human lung epithelial cells by Mycoplasma pneumoniae infection. J. Leukocyte Biol. Suppl.2001:p66, The Cytokine Odyssey 2001, Maui, Hawaii
5.Yang, J., Hooper, W. C., Phillips, D., and Talkington, D. (2002) Regulation of proinflammatory cytokines in human lung epithelial cells during Chlamydia pneumoniae infection. 102nd ASM General Meeting, Salt Lake City, Utah
6.Yang, J., Hooper, W. C., Phillips, D., and Talkington, D. (2002) Cell-type specific interleukin-1beta responses to Mycoplasma pneumoniae infection. 14th International Congress of IOM, Vienna, Austria
7.黄韵, 沈静, 余应年, 杨军. (2004) MNNG诱导FL细胞EGF受体聚簇及其对膜表面脂类代谢影响的研究. 中国病理生理学会9th肿瘤病理专业委员会及10th免疫病理专业委员会, 武汉, 湖北
8.杨军(2005)脂类组学研究MNNG对细胞脂类代谢的影响. 中国21世纪发展中心(863环境资源专题会议), 上海
9.杨军(2006) gammaH2AX: Biomarker for DNA double strand breaks. 中国环境诱变剂学会三致专业委员会年会, 郑州, 河南
10.杨军 (2006)系统生物学在生命科学研究中的应用. 亚太毒理学年会,珠海,广东
11.曾群力,沈静,陈帆青,杨军 (2006)纳米碳材料生物安全性的蛋白组学研究. 78届东方科技论坛,上海
12.Yang, J. (2006) A genomic, proteomic, and lipidomic response to environmental genotoxin MNNG. 37th Annual Environmental Mutagen Society, Vancouver, Canada
三、参编书籍:
1.生理科学实验指导,2004,浙江大学出版社,夏强主编,路源,魏尔清,杨军副主编
2.生物医学论著的英文写作(第二版),2005,浙江大学出版社,魏尔清主编
3.病理生理学(八年制),2005,人民卫生出版社,陈主初主编
四、研究基金
1.国家重点基础研究与发展计划(973)No. 2002CB512902 典型环境化学污染物致机体损伤及防御的基础研究
参加(负责人:卢大儒)¥3,000,000 200.12 – 2007.11
2.国家自然科学基金 No. 30300277 MNNG诱导的细胞表面受体聚簇的机理研究
负责人 ¥190,000 2004.01 – 2006.12
3.教育部回国人员启动基金
负责人 ¥25,000  2004.01 – 2005.12
4.国家高技术研究计划(863)No. 2004AA649120 应用H2AX检测环境遗传毒物的可能性研究
负责人 ¥270,000 2004.07 – 2006.6
5.国家自然科学基金 No. 30471956 MNNG诱导的细胞脱落蛋白的分离鉴定
负责人 ¥210,000 2005.01 – 2007.12
6.霍英东基金会青年教师基金 No. 101036
负责人 USD 20,000 2006.03 – 2009.03
7.教育部新世纪优秀人才支持计划 No. NCET-05-0520
负责人 ¥500,000 2006.01 – 2008.12

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