许华曦教授的研究主要致力于阐明AD发病的分子机制。综合遗传学、神经生物学、分子和细胞生物学信息等多学科，以阐明APP和早老素的正常生物学功能及其突变基因使蛋白发生改变而引起AD的机制。其团队的科研项目旨在研究Aβ转运和降解过程、tau蛋白异常磷酸化www.lindalemus.com，并试图寻找影响Aβ产生的新基因和遗传通路，研究目标在于揭示导致AD发病机理早期事件中的细胞和分子级联反应，并为开发合理的AD治疗策略提供关键信息。
主要学术成就：
论文
1 Xu, H. ,Sweeney, D.,Wang, R., Thinakaran, G..,Lo, A.C.Y., Sisodia, S., Greengard, P., and Gandy, S. (1997) Generation of Alzheimer ß-amyloid Protein in the trans-Golgi Network in the Apparent Absence of Vesicle Formation. Proc. Natl. Acad. Sci. USA. （影响因子10.789) 94:3748-3752. 
2  Xu, H., Gouras, G. K., Greenfield, J. P., Vincent, B., Naslund, J., Mazzarelli, L., Jovanovic, J. N, Seeger, M, Relkin, N. R, Liao, F., Checler, F., Buxbaum, J. D, Chait, B. T., Thinakaran, G., Sisodia, S., Wang, R., Greengard, P., and Gandy, S. (1998). Estrogen Reduces Neuronal Generation of Alzheimer ß-amyloid Peptides.  Nature Medicine （影响因子27.905)4:447-451. 
 3 Greenfield, J. P., Tsai, J., Gouras, G. K., Hai, B., Thinakaran, G., Checler, F., Sisodia, S. S., Greengard, P., and Xu, H.* (1999) Endoplasmic Reticulum and trans-Golgi Network Generate Distinct Populations of Alzheimer ß-Amyloid Peptides.  Proc. Natl. Acad. Sci. USA （影响因子10.789)96:742-747. 
 4 Gouras, G. K.¶, Xu, H.¶, Gross, R., Greenfield, J. P., Hai, B., Wang, R., and Greengard, P.  (2000) Testosterone Reduces Neuronal Secretion of Alzheimer ß-amyloid Peptides.  Proc. Natl. Acad. Sci. USA （影响因子10.789)97:1202-1205.  (¶, equal contribution).
5 Gasparini, L., Netzer, W., Greengard, P., and Xu, H *. (2002) Does Insulin Dysfunction Play a Role in Alzheimer's Disease.  Trends in Pharmacological Sciences （影响因子13.276)23(6):288-293. 
 6 Dou, F., Netzer, W. J., Tanemura, K., Li, F., Hartl, F.U., Takashima, A., Gouras G.K., Greengard, P., and Xu, H. * (2003) Chaperones increase association of tau protein with microtubules.  Proc. Natl. Acad. Sci. USA （影响因子10.789)100:721-726. www.lindalemus.com
7 Gasparini, L and Xu, H. * (2003) Potential roles of insulin and IGF-1 in Alzheimer's disease. Trends in Neurosciences （影响因子16.475)26(8):404-406. 
 8 Zhang, Y.W., Wang, R., Liu, Q., Zhang, H., Liao, F.F., Xu, H.* (2007) Presenilin/ g-secretase- dependent processing of APP regulates EGFR expression. Proc Natl Acad Sci USA (影响因子10.789)104: 10613-10618. 
 9 Zhang, Y.W., Liu, S., Zhang, X., Li, W.B., Chen, Y., Huang, X., Sun, L., Luo, W., Netzer, W.J., Threadgill, R., Wiegand, G., Wang, R., Cohen, SN., Greengard, P., Liao, F.F., Li, L., Xu, H..* (2009) A functional mouse retroposed gene Rps23r1 reduces Alzheimer’s b-amyloid levels and tau phosphorylation. Neuron (影响因子14.17)  64：328-340. 
 10 Zhang, Y-w., Xu, H. * (2010) Substrate check of gamma-secretase.Nat Struct Mol Biol（影   响因子12.273)17(2):140-141.

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