主要学术成果：

论文：

1

Wang Y, Yang D, Song L, Li T, Yang J, Zhang X, Le W* (2012) Mifepristone inducible caspase-1 expression in mouse embryonic stem cells eliminates tumor formation but spares differentiated cells in vitro and in vivo. Stem Cells. 30(2): 169-79.

2

Peng CG, Aron L, Klein R, Li M, Wurst W, Prakash N, Le W* (2011) Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons. J Neurosci. 31(36):12802-12815.

3

Yang DH, Li T, Wang Y, Yang J, Cui HJ, Tang Y, Zhang XJ, Chen DG, Shen N, Le W* (2012). miR-132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expression. Journal of Cell Science. [Epub ahead of print]

4

Heng X, Jin G, Zhang X, Yang DH, Zhu MZ, Fu SJ, Li XP, Le W* (2012) Nurr1 regulates Top IIbeta and functions in axon genesis of mesencephalic dopaminergic neurons. Molecular Neurodegeneration. [Epub ahead of print www.lindalemus.com]

5

Wang Z, Yang D, Zhang X, Li T, Li J, Tang Y, Le W* (2011) Hypoxia-induced down-regulation of neprilysin by histone modification in mouse primary cortical and hippocampal neurons. Plos one. 29;6(4):e19229.

6

Du Y, Yang D, Li L, Luo G, Li T, Fan X, Wang Q, Zhang X, Wang Y, Le W* (2009) An insight into the mechanistic role of p53-mediated autophagy induction in response to proteasomal inhibition-induced neurotoxicity. Autophagy. 5:1-13.

7

Li L, Zhang X, Yang D, Luo G, Chen S, Le W* (2009) Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP. Neurobiol Aging. 30:1091-1098.

8

Pu P and Le W* (2008) Dopamine neuron degeneration induced by MPP+ is independent of CED-4 pathway in Caenorhabditis elegans. Cell Res. 18(9):978-81.

9

Jankovic J, Chen S, Le W* (2005) The role of Nurr1 in the development of dopaminergic neurons and Parkinson’s disease. Prog Neurobiol. 77(1-2):128-38.

10

Le W, Xu P, Jankovic J, Jiang h, Appel SH, Smith RG, Vassilatis DK (2003) Mutations in NR4A2 associated with familial Parkinson disease. Nat Genet. 33(1):85-9.