1.HonganB,Costantini F,Lacy L,et al.Manipulating the mouse embryo-A Lab Manual ColdSping Harbor NY:Cold Spring Harbor Lab,1986,332-340

2.琦祖和，转基因动物技术，中华病理学杂志，1993，22：375

3.GordonJW ,Scangos GA,Plotdin DJ,et al Genetic transformation of mouse embryos byonicroinjection of purified DNA,Proc Natl Acad Sci USA,1980,77:7380

4.鄢盛恺，载鬲蛋白转基因小鼠的研究进展，国外医学临床生化化学家与检验分册，1996

5.BreslowJL,Transgenic mouse models of lipoprotein metabolism and atherosclerosis ProcNatl Acad Sci USA,1993,90:8314

6.BreslowJL,Insight into liporotein metabolism from studies in transgenic mince .Ann RevPhysid ,1994,56:797

7.何泉，王芳菲，陈兰英，心血管疾病转基因动物模型的建立，高血压杂志，1996，4：76

8.BrinsterRL,Chen HY ,Trwmbaaer ME,et al Factors affecting the efficency of introducingforewww.med126.comign DNA into mice by microinjecting eggs Proc Natl Aead SciUSA,1985,82:4438

9.EngerP,Haasch D,Pinkert CA,et al A strain-specific modifier on morse chromosome4controls the methyla tion of independent transgene loci,Cell,1991,65:9393

10.EricksonRP,Why isn"t a mouse more like a man?Trends Gen ,1989,5:1

11.PalmeterRD,Brinster RL,Hammer RE,et al Dramatic growth of mice that develop from eggsmicrojected with metallothinonein-growth lwrmone fusion germets ,Nature,1982,1300:611

12.胡以平，转基因小鼠一生命科学研究的新体系，自然杂志，1990，13：28

13.PiedrahitaJA,Zhang SH,Hagaman JR et al Generation of mice corrging a mutantapolipoprotein E gene inacfivated by gene targeting in embryowww.med126.comnic cells ProcNatl Acad Sci USA,1992,13:28

14.陈保生，载脂蛋白基因异常表达引起的高脂血症和动脉粥硬化及转基因技术在研究心血管疾病中的意义，中国循环杂志，1995，10：65

15.刘德培，方福德，梁植权，基因剔除，生理科学进展，1995，26：88

16.MansourSL,Thomas KR,Capecchi MR,Dsiruption of the proto oncogene int 2 in mouse embryoderived stem cells a general strategty for targeting mutations tonon-selectable genes ,Narure ,1988,336:348

17.PlumpSA,Smith JD,Hayek T,et al Severe hypercholesterolemia and atherosclerosis inapolipoprotein E-deficient mice created by homologous recombination in ES cellscell,1992,71:343

18.SauerB,Henderson N,Site specific DNA reambinaton in mammalian cells by the Crerecombinsae of bacteriophage P1,Proc Natl Acad Sci USA,1988,85:5166

19.CuH,Marth JD,Orban PC,et al.Deletion of a DNA polymerase βgene segment in Tcellsusing cell type specific gene targeting Scince,1994,265:103

20.RubinE,M,Kraurs R,M,Spangler E,A et al Inhibition of carly atherogenesis intransgenic mice by human apolipoprotein A I ,Nature ,1991,353:265

21.HayekT,Ito Y,Azrolan N,et al Dietray fat increases high denritylipoprotein(HDL)levels both by increasing the rtansport rates and decreasingthe fractional catabolic rates of HDL cholesterol ester and apolipoprotein(Apo)A I presentation of a new animal model and mechanistic studies in humanApoA I transgenic and control mice .J Clin Invest ,1993,91:1665

22.HayekT,C hajek-Shaul T,Walsh A,et al Probucol decreases allipoprotein A I tranrportrate and incresaes high density lipoprotein cholesteryl ester fractionalcatabolic rate in control and human apolipoprotein A I transgenic mice,Arterioscler Thromb,1991,11:1295

23.WilliamosnR,Lee D,Hegaman,Jet al Marked reduction of high denrity lipoprotein cholesterolin mice genetically modofice to lack apolipoprotein A I Proc Natl Acad SciUSA,1992,89:7234

24.ShultzJR ,Gong EL,McCall MR,et al.Expression of human apolipoprotein A-Ⅱand its effect on high density kliporoteins in tranrgenic mice ,JBiol Chem,1992,267:21630

25.SchultzJ,R,Verstryft J,Gong E L,et al Protein compositoin determines theanti-atherogenic properties of high densicty lipoproteins in transgenic miceNature ,1993,365:761

26.LintonMF ,Farese RV Jr,Chiesa G,et al.Transgenic mice ezpressing high plarmaconcentrations of human apolipoprotein B and lipoprotein(a),JclinInvest,1993,92:3029

27.CallowMJ,Stoltzfus LJ,Lawn RM,et al Expression of human apolipoprotein B and assemblyof lipoprotein (a)in transgenic mice Proc Natl Acad Sci USA,1994,92:21130

28.ItoY,Azrolan N,O Connell A,et al ,Hypertriglyceridermia as a result of humanapolipoprotein C-Ⅲgeneexpression in transgenic mice ,Science,1990,249:790

29,AaltSetala K,Fisher EA,Chen X,et al Mechanism of hypertriglycerdemia in humanapolipoprotein (Apo)CⅢ transgenicmice dimished very low density lipoprotein frctional catalbolic rate associatedwith increased ApocⅢ and reducedApoe on the partides J clin Invest,1992,90:1889

30.ShimanoH,Yamada N,Katsuki M,et al .Plasma lipoprotein metabolism in transgenic miceoverczpressing apolipoprotein E accelerated clearace of lipoproteins containingapolipoprotein B J Clin Invest,1992,90:2084

31.PasztyC,Macda N,Verstuylt,J,et al.Apolipoprotein A-i transgene corrects apolipoprteinE defieiency-induced atherosclerosis in nice ,j Clin Invest,1994,93:3301

32.ChiesaC,Hobbs HH,Koschinsky ML,et al Reconstitution of lipoprotein(a)by infusion ofhuman low density lipoprotein into transgeinc mice expressing humanapolipoprotein(a),J Biol Chem,1992,267:24369

33.LiuAC .Lawn RM,Verstugft JC,et al Human apolipoprotein A-I preventsatherosclerosis associated with apolipoprotein (a) in transgenic mice ,J LipidRes,1994,35:2263

34.AllisonJ,Campbell IL,Morahan Get al Diabetes in transgenic mice resulting fromnover-expression of classl histocompatibility molecules in pancreatinβcells,Nature ,1988,333:529

35.MarbanSL,Deloia JA,Gearhart JD,et la.Hyperinsulinemia in transgenic mice carryingmutiple copies of the human insuline gene,Dev Genet,1989

36.MackayK,Stnkert JL,Pinkert CA,et al.Glomeralosclerosis and renal cysts in micetransgenic for the early region of SV,Kidney Int ,1987,32:827

37.DoiT,Striker LJ,Quife C,et al Progressive glomeruloscleroxis develops inrtansgenic mice chronically ezpressing growth hormone and growth hormonereleasing factor but not in those expressing insulintide growth factor-1,Am J