| 公开(公告)号 | CN1218954C |
| 公开(公告)日 | 2005.09.14 |
| 申请(专利)号 | CN01118262.8 |
| 申请日期 | 2001.05.25 |
| 专利名称 | 人造血细胞相关基因-1 |
| 主分类号 | C07H21/00 |
| 分类号 | C07H21/00;C12N15/11;C12N15/12;C07K14/435 |
| 分案原申请号 | |
| 优先权 | |
| 申请(专利权)人 | 中国人民解放军军事医学科学院放射医学研究所 |
| 发明(设计)人 | 杨晓明;闾军;许望翔;江岩;;李长燕 |
| 地址 | 100850 北京市太平路27号放射医学研究所 |
| 颁证日 | |
| 国际申请 | |
| 进入国家日期 | |
| 专利代理机构 | |
| 代理人 | |
| 国省代码 | 北京;11 |
| 主权项 | 一种具有转化活性基因——人造血细胞分化相关基因-1，具有以下核苷酸序列：1GGTTATGAAGATAGGTACTGTGGGTGTTAGAAAGATTCACGGCAAAACAG51GGAAGCATCTAGGCTGCTTGTGGAAGTCAGACCAAAATAGCAGGAAGGTA101TTGCAGCAAGATGGATTTGGGAAAGGACCAATCTCATTTGAAGCACCATC151AGACACCTGACCCTCATCAAGAAGAGAACCATTCTCCAGAAGTCATTGGA201ACCTGGAGTTTGAGAAACAGAGAACTACTTAGAAAAAGAAAAGCTGAAGT251GCATGAAAAGGAAACATCACAATGGCTATTTGGAGAACAGAAAAAACGCA301AGCAGCAGAGAACAGGAAAAGGAAATCGAAGAGGCAGAAAGAAACAACAA351AACACAGAATTGAAGGTGGAGCCTCAGCCACAGATAGAAAAGGAAATAGT401GGAGAAAGCACTGGCACCTATAGAGAAAAAAACTGAGCCACCTGGGAGCA451TAACCAAAGTATTTCCTTCAGTAGCCTCCCCGCAAAAAGTTGTGCCTGAG501GAACACTTTTCTGAAATATGTCAAGAAAGTAACATATATCAGGAGAATTT551TTCTGAGTACCAAGAAATAGCAGTACAAAACCATTCTTCTGAAACATGCC601AACATGTGTCTGAACCTGAAGACCTCTCTCCTAAAATGTACCAAGAAATA651TCTGTACTTCAAGACAATTCTTCCAAAATATGCCAAGACATGAAGGAACC701TGAAGACAACTCTCCTAACACATGCCAAGTAATATCTGTAATTCAAGACC751ATCCTTTCAAAATGTACCAAGATATGGCTAAACGAGAAGATCTGGCTCCT801AAAATGTGCCAAGAAGCTGCTGTACCCAAAATCCTTCCTTGTCCAACATC851TGAAGACACAGCTGATCTGGCAGGATGCTCTCTTCAAGCATATCCAAAAC901CAGATGTGCCTAAAGGCTATATTCTTGACACAGACCAAAATCCAGCAGAA951CCAGAGGAATACAATGAAACAGATCAAGGAATAGCTGAGACAGAAGGCCT1001TTTTCCTAAAATACAAGAAATAGCTGAGCCTAAAGACCTTTCTACAAAAA1051CACACCAAGAATCAGCTGAACCTAAATACCTTCCTCATAAAACATGTAAC1101GAAATTATTGTGCCTAAAGCCCCCTCTCATAAAACAATCCAAGAAACACC1151TCATTCTGAAGACTATTCAATTGAAATAAACCAAGAAACTCCTGGGTCTG1201AAAAATATTCACCTGAAACGTATCAAGAAATACCTGGGCTTGAAGAATAT1251TCACCTGAAATATACCAAGAAACATCCCAGCTTGAAGAATATTCACCTGA1301AATATACCAAGAAACACCGGGGCCTGAAGACCTCTCTACTGAGACATATA1351AAAATAAGGATGTGCCTAAAGAATGCTTTCCAGAACCACACCAAGAAACA1401GGTGGGCCCCAAGGCCAGGATCCTAAAGCACACCAGGAAGATGCTAAAGA1451TGCTTATACTTTTCCTCAAGAAATGAAAGAAAAACCCAAAGAAGAGCCAG1501GAATACCAGCAATTCTGAATGAGAGTCATCCAGAAAATGATGTCTATAGT1551TATGTTTTGTTTTAACAATTCTCAACCATAAAGTTGTGGTCCAATGGAAC1601ATACAGCTTAATAGTTTATGCGTGATTTTCTCAAAATATTGTAAAACTTT1651TGACAATGCTCATTAATATTATTTTTTCTATTTGTAGACCATATCTGAAA1701GAAATAACATTTTTTAAGGCTCTACCACATAGACAATATCATGCTAGAAT1751GTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTATGTATAGGTCGGGGAGA1801GGATAGTGGTGGGAACAGACAAATAAGGAAGCGGGGAGGACTGGATAATT1851GGTTTTCCCCCCTAAGAACATTTATTTACGTCTTAAGAGCAGATAAGTGA1901CTAAGACTGAACACATACATTTTGTGGAGTATATAGTTTTCTTGTAAATG1951CTGTTCAATTATTAATGTAACAGTAGCATCAAAATTTTATTCAGGCTTTA2001GTTGACTCTTTTGGTCAGTTTTAACAATTCTCCTTAAAAGATATTTTGGA2051GTGATGAATGTAGTTTACTTTTGTATTTGAATTTTGATTTTCTATTTTTA2101TTTTTTAAATATTGTATTTGTGCACAATGTACATTAAATCATTATTACAT2151GAAAAAAAAAAAAAAA |
| 摘要 | 通过比较四月龄人胎肝组织及成年人肝组织基因表达差异，成功分离一种新基因，命名为造血细胞分化相关基因-1(Hemagene-1)。该基因mRNA全长2166bp核苷酸，包括110bp5’-非翻译序列，602bp3’-非翻译序列，Hemagene-1基因编码484氨基酸组成，分子量为55.3kd的蛋白质。该基因具有转化活性，高丰度表达在白血病细胞，与造血细胞分化密切相关。该基因可能用于诊断和治疗白血病。 |
| 国际公布 |
