公开(公告)号
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CN1436234A
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公开(公告)日
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2003.08.13
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申请(专利)号
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CN01806526.0
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申请日期
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2001.01.16
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专利名称
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用于前列腺癌治疗和诊断的组合物及方法
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主分类号
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C12N15/12
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分类号
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C12N15/12;C12N15/11;C12N1/21;C12N5/10;C07K14/47;C07K16/18;C07K19/00;A61K38/17;A61K48/00;G01N33/68;C12Q1/68;C12N5/08
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分案原申请号
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优先权
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2000.1.14 US 09/483,672
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申请(专利权)人
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科里克萨有限公司
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发明(设计)人
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徐江春;D·C·迪隆;J·L·密特查姆
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地址
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美国华盛顿州
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颁证日
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国际申请
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PCT/US01/01574 2001.1.16
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进入国家日期
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2002.09.13
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专利代理机构
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中国国际贸易促进委员会专利商标事务所
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代理人
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唐伟杰
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国省代码
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美国;US
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主权项
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一种分离的多核苷酸,其含有选自下列的序列:(a)SEQ ID NO:1-111,115-171,173-175,177,179-305,307-315,326,328,330,332-335,340-375,381,382和384-476,524,526,530,531,533,535,536,552,569-572,587,591,593-606,618-626,630,631,634,636,639-655,674,680,681,711,713,716,720-722,735,737-739,751,753,764,765,773-776和786-788所示的序列;(b)SEQ ID NO:1-111,115-171,173-175,177,179-305,307-315,326,328,330,332-335,340-375,381,382和384-476,524,526,530,531,533,535,536,552,569-572,587,591,593-606,618-626,630,631,634,636,639-655,674,680,681,711,713,716,720-722,735,737-739,751,753,764,765,773-776和786-788所示序列的互补序列;(c)由SEQ ID NO:1-111,115-171,173-175,177,179-305,307-315,326,328,330,332-335,340-375,381,382和384-476,524,526,530,531,533,535,536,552,569-572,587,591,593-606,618-626,630,631,634,636,639-655,674,680,681,711,713,716,720-722,735,737-739,751,753,764,765,773-776和786-788所示序列的至少20个连续残基组成的序列;(d)在中度严格条件下可与SEQ ID NO:1-111,115-171,173-175,177,179-305,307-315,326,328,330,332-335,340-375,381,382和384-476,524,526,530,531,533,535,536,552,569-572,587,591,593-606,618-626,630,631,634,636,639-655,674,680,681,711,713,716,720-722,735,737-739,751,753,764,765,773-776和786-788所示序列杂交的序列;(e)与SEQ ID NO:1-111,115-171,173-175,177,179-305,307-315,326,328,330,332-335,340-375,381,382和384-476,524,526,530,531,533,535,536,552,569-572,587,591,593-606,618-626,630,631,634,636,639-655,674,680,681,711,713,716,720-722,735,737-739,751,753,764,765,773-776和786-788所示序列有至少75%同一性的序列;(f)与SEQ ID NO:1-111,115-171,173-175,177,179-305,307-315,326,328,330,332-335,340-375,381,382和384-476,524,526,530,531,533,535,536,552,569-572,587,591,593-606,618-626,630,631,634,636,639-655,674,680,681,711,713,716,720-722,735,737-739,751,753,764,765,773-776和786-788所示序列有至少90%同一性的序列;和(g)SEQ ID NO:1-111,115-171,173-175,177,179-305,307-315,326,328,330,332-335,340-375,381,382和384-476,524,526,530,531,533,535,536,552,569-572,587,591,593-606,618-626,630,631,634,636,639-655,674,680,681,711,713,716,720-722,735,737-739,751,753,764,765,773-776和786-788所示序列的简并变体。
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摘要
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公开了用于治疗和诊断癌症(特别是前列腺癌)的组合物和方法。说明性组合物含有一种或多种前列腺特异的多肽、其免疫原部分、编码这些多肽的多核苷酸、表达这些多肽的抗原递呈细胞,和对于表达这些多肽的细胞特异的T细胞。例如,公开的这些组合物可用于诊断、预防和/或治疗疾病,特别是前列腺癌。
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国际公布
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WO01/51633 英 2001.7.19
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