姓名:徐立红
性别:女
籍贯:河南
所属学科:生物化学与分子生物学;劳动卫生与环境卫生学
职称:教授、博导
现任职务:生物化学与分子生物学教研室主任,劳动卫生与环境卫生研究所副所长
联系方式:
电话:
手机:13067709966
E-mail:xulihong@zju.edu.cn
学术团体和社会兼职:中国环境科学学会理事;中国环境诱变剂学会理事
学科专长:环境毒理学、生化毒理学
在研课题:
1.国家自然科学基金重点项目“典型化合物的环境危险性评价方法学基础研究”
2.863项目“用蛋白磷酸酶抑制法对毒素进行定性定量测定”
3.教育部博士点基金项目:微囊藻毒素对细胞凋亡的干扰及其致毒机理探讨
研究方向:
1.外源性物质对细胞信号转导和细胞凋亡的影响,毒理-蛋白质组学。
2.细胞信号转导与疾病、细胞凋亡与疾病、疾病蛋白质组学、疾病的分子诊断。
最后学历:博士
简历:
1985-1999.8 中科院水生生物研究所
1999.9-2003.6 浙江大学医学院公共卫生系
2003.6-至今 浙江大学医学院基础医学系
1986-1987 美国环保局德鲁斯实验室参加合作研究一年
1994年 日本名城大学药学系进行合作研究三个月
1995年 香港城市大学生物及化学系进行合作研究一个月
1997-1998年 香港城市大学生物及化学系做博士后一年
业绩一览:
一、发表文章
1.Xu Lihong, Zhang Yongyuan,, Paul K S Lam, Rudoff Wu, Ken-ichi Harada。Study of using fish protein phosphatase assay as biomarker to monitor okadaic class tumor rpomoters in water.“Asia Pacific Conference on Science and Management of Coastal Environment. Hong Kong, 1996”和“International Symposium on Environmental Chemistry and Toxicology, Sydney, Austrlia,1996”(墙报).
2.Xu Lihong,Zhou Bingsheng,Paul K S Lam, Chen Jiaping, Zhang Yongyuan, Ken-ichi Harada。 Study about intoxication mechanism of microcystins on fish. 3rd International Symposium on Aquatic Animal Health, 1998,Baltiomore, Maryland, USA (分会口头报告)
3.Xu Lihong, Zhang Yongyuan and Wang Deming。Fish enzymatic indicators in aquatic toxicology. The First Internationnl Symposium on fish Physiology. Fish Toxicology, and Fisheries Management, Guangzhou, PRC. (特邀报告), 1988.
4.Xu Lihong, Zhang Yongyuan, Xu Ying and Chen Zhuan. Effects of new insecticide CCU on Carps: acute toxicity and metabolism in vitro. Proceedingsof2nd international Symposium on fish Physiology, Fish Toxicology, and water quality Management, Sacromento, USA.(特邀报告)1990
5.张瑞祥,陶小南,张劲农, 向敏,张甬元,徐盈,徐立红, 液相色谱测定白三烯及其在临床和实验中的应用, 第一届国际华人胸肺疾病研讨会,1990.
6.张甬元,徐立红,徐盈,陈专。灭幼脲Ⅲ号在鱼体中的残留及代谢的研究. 全国环境生态毒理学会议, 1992
7.Ying Yiwei,Wang Zhaohui,Zhang Yongyuan,Xu Ying,Xu Lihong,Wu Wenzhong,Chen Guosheng。Ecotoxicoogical study of fenpropathrin on some common chinese aquatic organisms and evaluation of its effect on aquatic ecosystem. 3rd international sympoium fih phyiology toxicology and water quality management. Nanjin,PRC (特邀报告),1992
8.Xu Lihong,G J Zheng, P.K.S Lam, B.J Richardson, 1999. Relationship between tissue concentrations of polycyclic aromatic hydrocarbons and DNA adducts in green- lipped mussels (Perna viridis), Ecotoxicology, 8,73-82.
9.Xu Lihong, P K S Lam, Chen J P, Zhang Y Y, K-I Harada, 2000. Comparative Study on in vitro Inhibition of Fish and Mouse Protein Phosphatases by Microcystins, Environmental Toxicology, 5, 71-75.
10.Xu Lihong P K S Lam, Chen J P, Xu J M, Wong B S F, Zhang Y Y, R S S Wu and K-I Harada, 2000. Use of protein phosphatase inhibition assay to detect microcystins in Donghu Lake and a fish pond in china, Chemosphere,41,53-58. 11.Xu Lihong Zheng J S,Zhang Y Y, C C C Cheng and P K S Lam, 2001 Biomarker studies on gold-lined sea bream (Rhabdosargus sarba) exposed to benzo[a]pyrene. Water Science and Technology, 43:155-160.
12.Xu Lihong, Zhang, Y.Y., Lam, P.K.S. and Wong, B.S.F. 2001. Investigations on microcystins in Chinese water bodies - a review. Pp. 289-298. (Ed. B.M. Gawlik, B. Platzer & H. Muntau). In Freshwater Contamination in China: Current topics of research. Environment and Quality of Life Series. European Commission. (invited paper)
13.Xu Lihong, Zhou, B., Lam, P.K.S., Chen, J., Zhang, Y. and Harada, K.-I. 2002. In vivo protein phosphatase 2A inhibition and glutathione reduction by microcystin-LR in grass carp (Ctenopharyngodon idellus). In Proceedings of the Ninth International Conference on Harmful Algal Blooms, Hobart, Australia, 7-11 February 2000. (Ed. Hallegraeff, G.M., Blackburn, S., Bolch, C.J. and Lewis, R.) Pp. 399-402. Published by Intergovernmental Oceanographic Commission of UNESCO.
14.Bryan Wong, Paul K S Lam, Xu Lihong et al 1999. A colorimetric assay for screening microcystin class compounds in aquatic systems, Chemosphere,38,1113-1122.,
15.Chen G S, Xu Y, Xu Lihong et al Influence of dioxin and metal-contaminated sediment on phase I and II biotransformation enzymes in silver crucian carp, Ecotoxicology and Environmental Safety, 1998.,
16.Eric W.K. Ching, William H.L. Siu, Paul K.S. Lam, Xu Lihong et al, 2001. DNA Adduct Formation and DNA Strand Breaks in Green-lipped Mussels (Perna viridis) Exposed to Benzo[a]pyrene: Dose and Time Dependent Relationships, Marine Pollution Bulletin 42,603-610
17.W.H.L. Siu, J. Cao, R.W. Jack , R.S.S. Wu, B.J. Richardson, 徐立红, P.K.S. Lam. Application of the comet and micronucleus assays to the detection of B[a]P genotoxicity in haemocytes of the green-lipped mussel (Perna viridis) ,Aquatic Toxicology 66 ,2004,66:381–392.(SCI收录)
18.Xiaowei Zhang, Rudolf S.S. Wu, Wenyu Fu, 徐立红 , Paul K.S. Lam Production of reactive oxygen species and 8-hydroxy-20deoxyguanosine in KB cells co-exposed to benzo[a]pyrene and UV-A radiation Chemosphere (2004) 55: 1303–1308