特色:胰腺疾病的、手段和意义,实验/临床工作条件 主要研究成果: 主要论著 1.Lu Xia,Yaozong Yuan, Chundi Xu, et al.Effects of epidermal growth factor on the growth of human gastric cancer cell and the implanted tumor of nude mice. World J Gastroenterol 2002; 8(3):455 2.Lu Xia, Ying Bao, Yaozong Yuan, et al.All-trans retinoid acid-induced apoptosis in pancreatic cancer cells is mediated by bcl-2/bax and p53 expression. (2003年美国消化病周学术大会) 3.夏璐, 鲍英,袁耀宗, 等.全反式维甲酸和Caspase抑制剂Z-VAD-FMK对胰腺癌细胞凋亡的作用.胰腺病学,2003,3(4):198 4.夏璐, 袁耀宗.Bcl-2家族对细胞凋亡的作用及其在胰腺癌中的表达.国外医学消化分册,2003;23(4):152(综述) 5.夏璐, 鲍英,袁耀宗, 等.全反式维甲酸诱导胰腺癌细胞凋亡机制研究. 中华消化杂志 2004.7(24):391 6.鲍英,夏璐,袁耀宗, 等.康莱特对人胰腺癌细胞凋亡的实验研究.上海医学 2004;27(6):421 7.Lu Xia, Qihuang Jin, Yaozong Yuan, et al. Human acetylcholinesterase gene transfer in pancreatic cancer cells enhance the effect of all-trans retinoic acid induced apoptosis. J Gastroenterol Hepatol,2004,19(Suppl):A580(论文摘要) 8.Lu Xia, Ying Bao, Yaozong Yuan, et al. Immunohistochemical study of p53 , caspase-7 and bcl-2/bax in pancreatic cancer and chronic pancreatitis. Pancreas 2003;27(4):426 9.Ying Bao ,Lu Xia, Yaozong Yuan, et al. Kanglaite, an acetone extract of the Coix Seed, inhibits proliferation of human pancreatic cancer cells via cell cycle arrest and apoptosis. Pancreas 2003;27(4):424 10.Ying Bao, Yaozong Yuan, Lu Xia, et al.Neutral lipid isolated from endosperm of Job##s tears inhibits the growth of pancreatic cancer cells via apoptosis,G2/M arrest, and regulation of gene expression. J Gastroenterol and Hepatol 2005;20:1046-1053 11.沈俊,夏璐, 诸琦,等.芍药甙对犬急性重症胰腺炎奥狄括约肌功能的影响. 中国中西医结合消化杂志,2004,12(2):77 12.Lu Xia, Ying Bao, Yaozong Yuan, et al.The Effect of Histone H3 Acetylation on the Cell Cycle Arrest Induced by All-trans Retinoic Acid in Pancreatic Cancer Cells. J Gastroenterol Hepatol,2004,19(Suppl):A583 13.Lu Xia, Ying Bao, Yaozong Yuan, et al.All-trans retinoic acid induce alteration of specific chromatin acetylation via inhibition of histone deacetylase in pancreatic cancer cells.J Gastroenterol and Hepatol,2004,19(Suppl):A580 14.Lu Xia, Jihong Tan, Qi Zhu, et al.Value of miniprobe sonography in the evaluation of remission of ulcerative colitis. J Gastroenterol Hepatol,2004,19(Suppl):A659 15.夏璐, 金其煌,袁耀宗,等.人乙酰胆碱酯酶基因转染增强全反式维甲酸诱导胰腺癌细胞凋亡. 中华消化杂志2005,25(5):77 16.Y.Bao,Y.Yuan,L Xia. Neutral lipid isolated from endosperm of Job##s tears inhibits the growth of pancreatic cancer cells via apoptosis,G2/M arrest and regulation of gene expression.J Gastroenterol Hepato 2005,20:1046 17.L. Li, Y. Yuan, J. Lu, L. Xia. Treatment of pancreatic carcinoma by adenoviral mediated gene transfer of vasostatin in mice. Gut 2005,55: 259 主要参编著作 1.消化系统常见急诊:现代急诊内科学. 科学出版社. 2004 2.慢性胰腺炎发病机制与临床诊治:消化系疾病临床新技术.人民军医出版社. 2002 3.超声大肠镜:下消化道内镜学. 上海科学技术出版社. 2003 4.胰腺外分泌功能检查:中华内科学. 2004 5.急性胰腺炎、慢性胰腺炎:"面向21世纪"内科学.人民卫生出版社. 2001 6.食道正常功能和疾病-超声内镜:舒斯特胃肠动力学(第二版)上海科学文献出版社.2003
获奖情况 1.全反式维甲酸诱导胰腺癌细胞凋亡过程中p53和bcl-2/bax表达的变化2003年全国胰腺疾病大会优秀论文一等奖(第一作者) 2.Neutral lipid isolated from endosperm of Job##s tears inhibits the growth of pancreatic cancer cells via apoptosis,G2/M arrest, and regulation of gene expression.第12届欧洲消化病周优秀论文奖(2004)(课题设计,主要参加) 3.All-trans retinoic acid induce alteration of specific chromatin acetylation via inhibition of histone deacetylase during the cell cycle arrest in pancreatic cancer cells. 2005年 APDW Travel Award(第一作者) 4.2005年上海第二医科大学"百人计划" 5.2005年上海市卫生局高级西学中培养计划