浙大医学院病理学与病理生理学教授来茂德简介

论文、教材和著作: SCI收录论文51篇，最高影响因子8.894（2004年，是当时浙大医学院所有研究工作在本土完成的最高影响因子期刊论文)。已在本学科顶尖期刊如《J Path》、《Clin Cancer Res》、《Am J Surg Path》、《Mod Path》、《Histopathology》、《Virchows Arch》等杂志上发表了论文。中文论文100余篇。主编卫生部研究生规划教材《医学分子生物学》、副主编卫生部七年制和八年制规划教材《病理学》、几乎参加所有病理学方面的主要著作和教材。主编研究专著《上皮内瘤变》、《恶性肿瘤组织病理学分级图谱》、《 Intraepithelial Neoplasia》(该书全英文www.lindalemus.com，所有400多张病理图片都是中国人的，是国际上该领域的第一本专著，由中国高教出版社和世界著名图书出版公司Springer联合出版，目前在全世界销售，在国际病理学界有很好影响)。

近年来代表性论文：
1.Lin J, Lai M, Huang Q, Ma Y, Cui J, Ruan W. Methylation patterns of IGFBP7 in colon cancer cell lines are associated with levels of gene expression. The Journal of pathology 2007;212: 83-90.
IF 5.423
2.Lu B, Xu J, Zhu Y, Zhang H, Lai M. Systemic analysis of the differential gene expression profile in a colonic adenoma-normal SSH library. Clinica chimica acta; international journal of clinical chemistry 2007;378: 42-7.
IF 2.601
3.MD L, Xujing. Ribosomal proteins and colorectal cancer. Current Genomics 2007;8: 43-9.
IF 0.573
4.Ruan W, Lai M. Actin, a reliable marker of internal control? Clinica chimica acta; international journal of clinical chemistry 2007;385: 1-5.
IF 2.601
5.Ruan W, Xu E, Xu F, et al. IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis. Cancer biology & therapy 2007;6: 354-9. www.lindalemus.com
IF 2.873
6.Wang Y, Ma Y, Lu B, Xu E, Huang Q, Lai M. Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study. Exp Biol Med (Maywood) 2007;232: 1152-9.
IF 1.979
7.Xu E, Xia X, Lu B, et al. Association of matrix metalloproteinase-2 and -9 promoter polymorphisms with colorectal cancer in Chinese. Mol Carcinog 2007.
IF 3.194
8.Xu F, Wang F, Di M, et al. Classification based on the combination of molecular and pathologic predictors is superior to molecular classification on prognosis in colorectal carcinoma. Clin Cancer Res 2007;13: 5082-8.
IF 6.25
9.Ye F, Chen Y, Knosel T, et al. Decreased expression of insulin-like growth factor binding protein 7 in human colorectal carcinoma is related to DNA methylation. Journal of cancer research and clinical oncology 2007;133: 305-14.
IF 2.366
10.Zhu Y, Lai M, Yang H, et al. Genotypes, haplotypes and diplotypes of XPC and risk of bladder cancer. Carcinogenesis 2007;28: 698-703. www.lindalemus.com
IF 5.406
11.Zhu YM, Huang Q, Lin J, Hu Y, Chen J, Lai MD. Expression of human DNA methyltransferase 1 in colorectal cancer tissues and their corresponding distant normal tissues. International journal of colorectal disease 2007;22: 661-6.
IF 1.918
12.Kang L, Lu B, Xu J, Hu H, Lai M. Downregulation of Kruppel-like factor 9 in human colorectal cancer. Pathol Int 2008;58: 334-8.
IF 1.371
13.Lu B, Fang Y, Xu J, et al. Analysis of SOX9 expression in colorectal cancer. Am J Clin Pathol 2008;130: 897-904.
IF 2.629
14.Lu B, Xu J, Chen J, Yu J, Xu E, Lai M. TaqMan low density array is roughly right for gene expression quantification in colorectal cancer. Clinica chimica acta; international journal of clinical chemistry 2008;389: 146-51.
IF 2.601

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