三、在研的主要项目
1.近年主要研究课题
(1) 哮喘发病的分子机制和干预策略研究,国家杰出青年科学基金。
(2) 呼吸疾病基础――磷酸酶SHP2信号在肺损伤和异常修复中的调控机制,国家973项目。
(3) 趋化素样因子1衍生多肽作为候选新药的研究与开发, 国家863项目。
(4) TLR4-PKC-Duox1信号通路在PA-LPS上调气道粘蛋白MUC5AC中的作用,国家自然科学基金。
(5) 中医药在哮喘阶梯式治疗中优化方案的研究,十一五国家科技支撑计划课题。
代表论文
主要SCI收录论文
1. Jiyong J, Tiancha H, Wei C, Huahao S. Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. Intensive Care Med. 2009,35(4):587-595.
2. Jing JY, Huang TC, Cui W, Xu F, *Shen HH. Should FEV1/FEV6 replace FEV1/FVC ratio to detect airway obstruction? A metaanalysis.Chest. 2009, Apr;135(4):991-8.
3. Li Q, *Shen HH. Neonatal bacillus Calmette-Guérin vaccination inhibits de novo allergic inflammatory response in mice via alteration of CD4+CD25+ T-regulatory cells. Acta Pharmacol Sin. 2009 Jan;30(1):125-33.
4. Zhang GS, Wang PL, Huang HQ, *Shen HH. New insights into the effects of Mycobacterium bovis Bacillus Calmette-Guérin on asthma.Chin Med J (Engl). 2009 Mar 5;122(5):577-83.
5. Wang P, Zhang G, *Shen HH. Multiple synchronous primary malignancies induced by benzene exposure: a case report. J Occup Med Toxicol. 2009 Apr 16;4:7.www.lindalemus.com
6. Gao GX, Li QM, *Shen HH. Effect of Astragali-Cordyceps Mixtura on TGF-beta/Smad signal pathway in the lung of Asthma Airway Remodeling. J Ethnopharmacol. 2009 Jun 20. [Epub ahead of print]
7. *Shen H, Huang H, Wang J, Ye S, Li W, Wang K, Zhang G, Wang P. Neonatal vaccination with Bacillus Calmette-Guerin elicits long-term protection in mouse allergic responses. Allergy ,2008, 63: 555-563.
8. Ben SQ, Li XB, Xu F, Xu WH, Li W, Wu ZQ, Huang HQ, Shi GZ, *Shen HH. Treatment with anti-CCR3 monoclonal antibody or dexamethasone inhibits the migration and differentiation of bone marrow CD34+ progenitor cells in an allergic mouse model. Allergy, 2008 Sep;63(9):1164-76.
9. *Shen HH, Yoshida H, Yan FG, Li W, Xu F, Huang HQ, Jono H, Li JD. Synergistic induction of MUC5AC mucin by nontypeable Haemophilus influenzae and Streptococcus pneumoniae. BBRC, 2008, 365(4):795-800.
10. Fugui Yan, Hirofumi Jono, Jian-Dong Li,*Shen HH. Reactive oxygen species regulates Pseudomonas aeruginosa Lipopolysaccharide-induced MUC5AC mucin expression via PKC-NADPH oxidase-ROS-TGF-alpha signaling pathways in human airway epithelial cells. BBRC , 2008,366: 513–519.
11. Liu GN, Shi HZ, Xie ZH, Shen HH, Huang HQ, Deng JM, Liang QL, Wu YB. Epithelial Neutrophil-Activating Peptide-78 Recruits Neutrophils into Pleural Effusion.Eur Respir J. 2008 Dec 1. [Epub ahead of print]
12. Xu F, Xu ZH, Zhang R, Wu ZQ, Li JD, *Shen HH. Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B. Respiratory Research 2008, 9(1):16。