四、专利
1. 通过MAPKAPK2基因检测肺癌易感性和判断肺癌预后的试剂盒及其用途。专利（申请)号：CN201010538875.9；公开（公告)号：CN101974637A.
2. 通过MAP2K4基因检测肺癌易感性的试剂盒及其用途，2010年申报国家发明专利。专利（申请)号：CN201010538851.3；公开（公告)号：CN101974636A.
五、近年发表论文：
1. Lu J*(吕嘉春corresponse), Yang L, Zhao H, Liu B, Li Y, Wu H, Li Q, Zeng B, Wang Y, Ji W, Zhou Y. The polymorphism and haplotypes of PIN1 gene are associated with the risk of lung cancer in Southern and Eastern Chinese population. Hum Mutat. 2011 Aug 17. doi: 10.1002/humu.21574. [Epub ahead of print] (SCI IF=5.956)
2. Liu B(刘斌), Chen D, Yang L, Li Y, Ling X, Liu L, Ji W, Wei Y, Wang J, Wei Q, Wang L, Lu J*(吕嘉春corresponse), A functional variant (-1304T>G) in the MKK4 promoter contributes to a decreased risk of lung cancer by increasing the promoter activity. Carcinogenesis, 2010 Aug;31(8):1405-11. Epub 2010 Jun 16. (SCI IF=5.402)
3. Yang L(杨磊), Li Y, Cheng M, Huang D, Zheng J, Liu B, Ling X, Li Q, Zhang X, Ji W, Zhou Y, Lu J*(吕嘉春corresponse), A functional polymorphism at microRNA-629 binding site in the 3’-untranslated region of NBS1 gene confers an increased risk of lung cancer in Southern and Eastern Chinese population. Carcinogenesis, 2011 Sept;19. Accepted. (SCI IF=5.402)
4. Yang L(杨磊), Li Y, Ling X, Liu L, Liu B, Xu K, Bin X, Ji W, Lu J*(吕嘉春corresponse), A common genetic variant (97906C>A) of DAB2IP/AIP1 is associated with an increased risk and early onset of lung cancer in Chinese males. PLoS One. 2011 Sept;13. Accepted. (SCI IF=4.411)
5. Zheng J#, Liu B#(刘斌, co-first author), Zhang L#, Jiang L, Huang B, You Y, Jiang Q, Zhang S, Lu J*(吕嘉春corresponse), ZhouY*.The protective role of polymorphism MKK4 -1304 T>G in nasopharyngeal carcinoma is
www.lindalemus.com modulated by Epstein-Barr virus’ infection status. Int J Cancer. 2011 Jun 23. doi: 10.1002/ijc.26253. [Epub ahead of print] (SCI IF=4.926)
6. Wei Y, Wang L, Lan P , Zhao H, Pan Z, Huang J, Lu J*(吕嘉春corresponse) ,Wang J*. The association between -1304T>G polymorphism in the promoter of MKK4 gene and the risk of sporadic colorectal cancer in southern Chinese population. Int J Cancer. 2009 May 15;125(8): 1876-1883. (SCI IF=4.734)
7. Jiang L#, Zhang C#, Li Y#（黎银燕, co-first author), Yu X, Zheng J, Zou P, Li Y, Bin X, Lu J*(吕嘉春corresponse), Zhou Y*. A non-synonymous polymorphism Thr115Met in the EpCAM gene is associated with an increased risk of breast cancer in Chinese population. Breast Cancer Res Treat. 2011 March 15, 126(2):487–495. Epub 2010 Aug 4. (SCI IF=4.859)
8. Lu M*, Lu J*(吕嘉春corresponse), Yang X, Yang M, Tan H, Yun B, Shi L. Association between the NBS1 E185Q polymorphism and cancer risk: a meta-analysis. BMC Cancer. 2009,9:124. (SCI IF=3.087)
9. Lu J(吕嘉春), Hu Z, Wei S, Wang LE, Liu Z, El-Naggar AK, Sturgis EM, Wei Q*. A Novel Functional Variant (-842G>C) in the PIN1 Promoter Contributes to Decreased Risk of Squamous Cell Carcinoma of the Head and Neck by Diminishing the Promoter Activity. Carcinogenesis. 2009 Oct;30(10):1717-21. Epub 2009 Jul 22. (SCI IF=5.406)
10. Lu J(吕嘉春), Wei Q, Bondy ML, Li D, Brewster A, Shete S, Yu TK, Sahin A, Meric-Bernstam F, Hunt KK, Singletary SE, Ross MI, Wang LE*. Genetic variants in the promoter region of H2AX are associated with risk of sporadic breast cancer in non-Hispanic white women aged £ 55 years. Breast Cancer Res Treat. 2008 Jul;110(2):357-66. Epub 2007 Sep 13. (SCI IF=5.684)
11. Lu J(吕嘉春), Wang LE, Xiong P, Sturgis E M, Spitz M R, Wei Q*. 172G>T variant in the 5¢ untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant. Carcinogenesis. 2007 May;28(5):988-994. (SCI IF=5.406)
12. Lu J(吕嘉春), Wei Q, Bondy ML, Li D, Brewster A, Shete S, Yu TK, Sahin A, Meric-Bernstam F, Hunt KK, Singletary SE, Ross MI, Wang LE*. Polymorphisms and haplotypes of the NBS1 gene are associated with risk of sporadic breast cancer in non-Hispanic white women <= 55 years. Carcinogenesis. 2006, May 19 19;27(11)2209-2216. (SCI IF=5.366)
13. Lu J(吕嘉春), Wei Q, Bondy ML, Yu TK, Li D, Brewster A, Shete S, Sahin A, Meric-Bernstam F, Wang LE*. Promoter polymorphism (-786t>C) in the endothelial nitric oxide synthase gene is associated with risk of sporadic breast cancer in non-Hispanic white women age younger than 55 years. Cancer. 2006, Nov 1; 24;107(9):2245-2253. (SCI IF=4.80)
14. Han CH, Lu J(吕嘉春,co-first author), Wei Q, Bondy ML, Brewster AM, Yu TK, Buchholz TA, Arun BK, Wang LE*. The functional promoter polymorphism (-842G>C) in the PIN1 gene is associated with decreased risk of breast
www.lindalemus.com cancer in non-Hispanic white women 55 years and younger. Breast Cancer Res Treat. 2010, 122(1):243-249. Epub 2009 Dec 24. (SCI IF=5.684)
15. Zhong N(钟南山), Wang C, Yao W, Chen P, Kang J, Huang S, Chen B, Wang C, Ni D, Zhou Y, Liu S, Wang X, Wang D, Lu J(吕嘉春, co-first author), Zheng J, Ran P*. Prevalence of Chronic Obstructive Pulmonary Disease in China: A Large Population-based Survey. Am J Respir Crit Care Med. 2007 Oct 15;176(8):753-60. Epub 2007 Jun 15. Erratum in: Am J Respir Crit Care Med. 2007 Dec 1;176(11):1169. (SCI IF=9.091)
16. Zhou Y, Wang C, Yao W, Chen P, Kang J, Huang S, Chen B, Wang C, Ni D, Wang X, Wang D, Liu S, Lu J(吕嘉春, co-first author), Zheng J, Zhong N, Ran P*. COPD in Chinese nonsmokers. Eur Respir J. 2009; 33(3): 1-10. (SCI IF=5.545)
17. Lu M, Yao W, Zhong N, Zhou Y, Wang C, Chen P, Kang J, Huang S, Chen B, Wang C, Ni D, Wang X,Wang D, Liu S, Lu J(吕嘉春, co-first author), Shen N, Ran P*. Asymptomatic patients of chronic obstructive pulmonary disease in China. Chin Med J (Engl). 2010 Jun;123(12):1494-9.
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